This comprehensive handbook and textbook of geographical concepts is directed to scholars and students of geography, economics, political science and other social sciences who are interested in the relationship between economy and space. This book systematically discusses classical and new theories in economic geography and related disciplines. Beginning with a critical review of traditional regional science and optimal location approaches, the authors develop a relational conception of economic action in space that enables interdisciplinary analyses of globalization processes. This completely restructured and extended edition adds many new conceptual discussions, such as those on innovation systems, global value chains, clusters and many others. Six new chapters, almost 200 new pages and many new case studies, figures and tables make this a rich sourcebook for those interested in understanding economic action in spatial perspective.